Article description

Summary:

• Comparing the anti-inflammatory and antioxidant effects of propofol and sevoflurane in children with cyanotic congenital heart disease (CCHD) undergoing cardiac surgery with CPB.
• Prospective, randomized, double-blind study.
• Single center, university hospital in Adana, Turkey.
• 1–10-year-old children with CCHD, elective cardiac surgery with cardiopulmonary bypass.
• Randomization into general anesthesia with either sevoflurane (group S) or propofol (group P).
• SIRS occurrence was assessed at the end of the surgery and the 6^th, 12^th, and 24^th postoperative hours.
• Blood samples were obtained four times: after anesthesia induction (T0), after release of the aortic cross-clamp (T1), at the end of the surgery (T2), and postoperative 24th hour (T3). The serum levels of interleukin 6 and tumor necrosis factor-alpha, and the total antioxidant status (TAS) and total oxidant status, were analyzed.
• Results: SIRS is more common in group S than in group P at all times (p = 0.020, p = 0.036, p = 0.004, p = 0.008). No significant differences between the groups in the mean tumor necrosis factor-alpha and interleukin 6 levels at any time. The TAS level at T2 was higher in group P than in group S (p = 0.036). The serum TAS level increased at T2 compared with T0 in group P, but it decreased in group S (p = 0.041).

Conclusions:

• Results showed propofol provided a greater antioxidant effect and reduced SIRS postoperatively more than sevoflurane in these children.