Regional Cerebral Oxygen Saturation to Predict Favorable Outcome in Extracorporeal Cardiopulmonary Resuscitation: A Systematic Review and Meta-Analysis

URL: https://www.jcvaonline.com/article/S1053-0770(23)00006-X/fulltext

DOI: 10.1053/j.jvca.2023.01.007

Published online: Journal of Cardiothoracic and Vascular Anesthesia, 9 January, 2023

Authors: Pietro Bertini, Alberto Marabotti, Gianluca Paternoster, Giovanni Landoni, Fabio Sangalli, Adriano Peris, Manuela Bonizzoli, Sabino Scolletta, Federico Franchi, Antonio Rubino, Matteo Nocci, Niccolo Castellani Nicolini, Fabio Guarracino

Article description

Summary:
  • The meta-analysis aim was to investigate the role of regional cerebral oxygen saturation (rSO2) in predicting survival and neurologic outcomes after extracorporeal cardiopulmonary resuscitation (ECPR);
  • Systematic review and meta-analysis of all available literature;
  • The study included three retrospective cohort studies with 245 patients;
  • A high pre-cannulation rSO2 was associated with an overall reduced risk of mortality in ECPR recipients (64.9% in the high rSO2 group vs. 92.5% in the low rSO2 group, RD -0.30; 95% CI -0.47 to -0.14);
  • A high pre-cannulation rSO2 was associated with a statistically significant increase in the probability of a good neurologic outcome ([27.8% vs. 2.12%, RD 0.22; 95% CI 0.13-0.31).
Conclusions:
  • Regional cerebral oxygen saturation could be a predictive marker of positive neurologic outcomes and survival in patients undergoing extracorporeal cardiopulmonary resuscitation after cardiac arrest;
  • Further studies are needed in order to evaluate cerebral oxygen saturation possible use in clinical practice.

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